Diffuse gastric cance (poorly differentiated adenocarcinoma) gastric cancer, poorly differentiated, diffuse, scirrhous, signet-ring cell
Conditions
Interventions
FAPI-PET, positron emission tomography, 18F-FAPI-74
Sponsors
Akashi Yoshimasa
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who meet all of the following criteria are eligible for this study. 1) Patients diagnosed with gastric cancer based on upper gastrointestinal endoscopy and pathological tissue biopsy 2) Patients with low-differentiated adenocarcinoma (por, por1, por2) or signet ring cell carcinoma (sig) components detected in preoperative tissue biopsy 3) Patients undergoing curative surgery for gastric cancer or diagnostic laparoscopy 4) Patients aged 18 years or older at the time of informed consent 5) Patients who have received adequate explanation regarding participation in this trial, demonstrated sufficient understanding, and provided written informed consent of their own free will.
Exclusion criteria
Exclusion criteria: Patients who meet any of the following criteria shall not be included in this trial. 1) Patients with a history of gastrectomy and residual gastric cancer 2) Patients with severe renal disease (BUN >=25 mg/dL or serum creatinine >=2.0 mg/dL) 3) Pregnant women or women who may be pregnant or wish to become pregnant 4) Women who are breastfeeding 5) Patients with phenylketonuria 6) Other patients deemed ineligible for participation by the principal investigator or co-investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The accuracy rate of preoperative staging diagnosis (T-, N-, and M- staging) for conventional examination alone or FAPI-PET added diagnosis. | — |
Secondary
| Measure | Time frame |
|---|---|
| Detection rate of 18F-FAPI-PET examination for primary gastric cancer lesions Detection rate of 18F-FAPI-PET examination for metastatic gastric cancer lesions Accuracy rate of primary tumour progression diagnosis in gastric cancer Correlation between fibrosis and FAP immunohistochemical evaluation in surgical resection specimens Correlation between 18F-FAPI-PET uptake (SUV values) and blood tumour markers Ability to distinguish tumour uptake from non-tumour uptake using early and delayed phase imaging | — |
Contacts
Public ContactYoshimasa Akashi
University of Tsukuba Hospital
Outcome results
None listed