Nonfunctioning pituitary neuroendcrine tumor pituitary neuroendocrine tumor
Conditions
Interventions
Sodium chloride load
Sponsors
Kino Hiroyoshi
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients who have undergone endoscopic endonasal surgery for non-functioning pituitary neuroendocrine tumors 2) Patients with normal serum sodium levels 3) Patients who are between 18 and 75 years of age at the time of consent 4) Patients who have been fully informed of the study and have given their voluntary written consent based on their full understanding.
Exclusion criteria
Exclusion criteria: 1) Patients on preoperative medication for endocrine dysfunction 2) Patients with pre- or post-operative diabetes insipidus (including transient) requiring medication 3) Patients with uncontrolled hypertension 4) Patients with a history of myocardial infarction, heart failure, or unstable angina 5) Patients with severe renal dysfunction (BUN over 25 mg/dL or serum creatinine over 2.0 mg/dL) 6) Pregnant and potential pregnant women 7) women who are breastfeeding 8) Patients who received other study or investigational products within 3 months prior to the start of study drug administration 9) Patients with prolonged postoperative impaired consciousness and difficulty in pain assessment 10) Patients deemed inappropriate as subjects by the investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence and safety evaluation of hypernatremia, hypertension, and renal dysfunction associated with salt loading (1.8 g/day, 5 days) | — |
Secondary
| Measure | Time frame |
|---|---|
| Frequency, timing, and grade of hyponatremia on postoperative days 3 through 7, and evaluation of risk factors for the development of hyponatremia. | — |
Contacts
Public ContactHiroyoshi Kino
University of Tsukuba Hospital
Outcome results
None listed