Keratoconjunctivitis caused by Mpox virus
Conditions
Interventions
Starting 2 weeks: 1 drop in the affected eye every 2 hours while awake (maximum of 9 drops per eye per day).
Subsequent 1 week: 1 drop in the affected eye every 4 hours while awake (minimum 5 drops pe
Sponsors
Morioka Shinichiro
Ohmagari Norio
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: All of 1) to 2) must be met. 1) Who are 6 years of age or older at the time of obtaining consent. 2) Those who have been diagnosed with keratoconjunctivitis caused by the Mpox virus. However, the diagnosis of empoxvirus shall be made when the pathogen is detected in conjunctival swab fluid by the following methods. Direct observation of virus particles by electron microscopy Detection of pathogens by separation and identification Detection of pathogen antigens by fluorescent antibody method Detection of pathogen genes by PCR
Exclusion criteria
Exclusion criteria: 1) Patients who have had anaphylaxis or serious systemic reactions to trifluridine in the past 2) Persons deemed inappropriate for inclusion in the study by the principal investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is the sum of the scores obtained by evaluating the following items. Eyelid skin findings: erythema, swelling, skin rash Conjunctival findings: hyperemia of the bulbar conjunctiva, elevated lesions/ulcers, ocular grease Corneal findings: superficial keratitis, infiltrates/ulcers, corneal opacity Other findings: corneal perforation, endophthalmitis, ocular inflammation | — |
Secondary
| Measure | Time frame |
|---|---|
| Viral load of conjunctival swab 7, 14, 21, and 30 days after test inclusion | — |
Contacts
Public ContactSho Saito
National Center for Global Health and Medicine
Outcome results
None listed