Helicobacter pylori infection Helicobacter pylori
Conditions
Interventions
If a positive Helicobacter pylori culture test is confirmed after study registration, the following therapeutic interventions will be performed. If the test result is negative, no therapeutic interven
Sponsors
Sue Soichiro
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Patients diagnosed with Helicobacter pylori infection. (2) Failed national insurance covered first-line eradication treatment (7-day treatment with 3 drugs of vonoprazan or PPI, amoxicillin, and clarithromycin) and national insurance covered second-line eradication treatment (7-day treatment with 3 drugs of vonoprazan or PPI, amoxicillin, and metronidazole), or , People who are unable to receive national insurance covered first-line, second-line eradication treatment due to penicillin allergy. (3) Patients who can provide written consent to participate in this study
Exclusion criteria
Exclusion criteria: (1) Patients with a history of hypersensitivity to rifabutin or rifampicin (2) Patients receiving the following drugs: voriconazole, grazoprevir, elbasvir, ticagrelor, artemether/lumefantrine, rilpivirine/tenofovir, alafenamide/emtricitavir, ensitrelvir, nirmatrelvir/ritonavir, avigan, rilpivirine, isavuconazonium, atazanavir sulfate, rilpivirine hydrochloride (3) Patients with hypersensitivity to sitafloxacin or other quinolone antibiotics (4) Those who are pregnant or may be pregnant (5) Patients currently diagnosed with drug allergy due to vonoprazan (6) Patients with other serious diseases (liver failure, renal failure, etc.). (The standard for liver function is total bilirubin 1.5 mg/dL or less, and the standard for renal function is creatinine 1.2 mg/dL or less.) (7) Other patients who are judged to be inappropriate by the doctor's judgment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication rate | — |
Secondary
| Measure | Time frame |
|---|---|
| Treatment compliance, Safety | — |
Contacts
Public ContactSoichiro Sue
Yokohama City University Hospital
Outcome results
None listed