septic shock
Conditions
Interventions
For patients receiving more than 0.2 gamma of noradrenaline, a 1U bolus dose of vasopressin is administered.
Sponsors
Nakamura Kensuke
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Age at enrollment is 20 years or older (2) Patients diagnosed with septic shock based on Sepsis-3 (requiring noradrenaline or other hypertensive drugs to maintain an average blood pressure of 65 mmHg or higher despite adequate infusion load, and blood lactate level of 2 mmol/L or higher) (3) Patients receiving noradrenaline 0.2 gamma or higher
Exclusion criteria
Exclusion criteria: (1) Participated in this clinical study in the past (2) Patients who are otherwise judged by the physician to be inappropriate for inclusion in the study (3) Patients for whom the administration of this drug is contraindicated (4) Patients who cannot find a surrogate and whose state of consciousness is not expected to improve
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lactate change before and 2 hours after administration | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of ICU stay, total hospital stay, catecholamine index at 2, 4, 6, and 24 hours, duration of ventilation, duration of hemodialysis, 24-hour IN/OUT/NET balance and urine output, blood gas findings before and after and at 24 hours, adverse events (limb/intestinal/myocardial ischemia, 30-day in-hospital deaths), steroid use | — |
Contacts
Public ContactShinya Suganuma
Yokohama City University Hospital
Outcome results
None listed