Not limited
Conditions
Interventions
Remifentanil concentration is kept constant and remimazolam concentration is gradually increased, or remimazolam concentration is kept constant and remifentanil concentration is gradually increased
Sponsors
Masui Kenichi
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Patients aged between 18 and 89 years undergoing general anesthesia for elective surgery at Yokohama City University Hospital (2) Patients who have an arterial catheter inserted into the radial artery for intraoperative and postoperative blood pressure measurements or blood sampling (3) Patients who have given written consent to participate in this study
Exclusion criteria
Exclusion criteria: Patients for whom remimazolam, remifentanil, and rocuronium are contraindicated in the Japanese package inserts; patients receiving benzodiazepines for >=1 week within 3 months; patients with a history of drug dependence; organic brain disease; pregnant and lactating women; American Society of Anesthesiologists physical status is >=3; body mass index >=30 kg/m2; Glasgow coma scale <15; or patients deemed ineligible by the study physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Remimazolam and remifentanil effect-site concentrations at loss of consicousness, and to suppress the sympathetic response to laryngoscopy and tracheal intubation | — |
Secondary
| Measure | Time frame |
|---|---|
| Electroencephalogram monitoring, invasive arterial blood pressure , heart rate, and effect-site concentrations fof remimazolam and remifentanil | — |
Contacts
Public ContactKenichi Masui
Yokohama City University Hospital
Outcome results
None listed