Healthy adult
Conditions
Interventions
45 minutes continuous scan followed by 111MBq bolus injection of 123I-IMP.
Sponsors
Hirano Shigeki
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Those who meet all the following conditions are eligible. 1) Age at consent between 20 to 85. 2) Person who are capable of conducting studies within required period. 3) Subjects who have no problem if neuropsychological examination is performed within 3 months before obtaining informed consent 4) Subjects who are age-appropriate and have no problems if a head MRI scan has been performed within 3 months before obtaining informed consent 5) Subjects who have no problem in neuropsychological examination in the screening test after obtaining informed consent 6)Subjects who have age-appropriate brain MRI images and no problems in the screening test after obtaining informed consent 7)Person who are capable of providing written consent
Exclusion criteria
Exclusion criteria: Those who meet any of the following conditions are not eligible. 1) Those who are pregnant, or possible pregnancy, or breastfeeding. 2) Those with prior neurological or psychiatric disorders which could interfere with cognitive function. 3) Those with severe physical problem (e.g. in liver, kidney, or endocrine system). 4) Those having prior serious head trauma. 5) Those who are unable to perform MRI (i.e. metallic implants, claustrophobia, tatoos). 6) Those who have impared cognitive function. 7) Those who are incapable of completing the study, judged by the physician.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The average cerebral blood flow of whole brain in group of young, middle-aged, and elderly individuals. | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety: Frequency of All Adverse Events Efficacy: 1) Total MMSE score 24 or above are required. 2) ACEIII (Addenbrooke's Cognitive Examination Cognitive III) screening tests, consist of five cognitive domain (attention, memory, fuency, language, visuospatial). Total test time : 15 to 20 mins. 3) MoCA-J (Japanese version of Montreal Cognitive Cognitive Assessment) Screening testformild cognitive impairment. Total test time : 10 mins. 4) Japanese version of 4 A's test (4AT) is a screening test for delirium. Total test time 1 to 2 mins. 5) AQ-J (Japanese version of Autism spectrum Quotient) Assessment test for autism spectrum disorder. Total test time :10 mins. 6) BIS11(Barratt Impulsiveness Scale)Assessment test for impusiveness. Total test time : 10 mins. 7) BIS/BAS(Japanese version of ehavioral Inhibition System/Behavioral Activation System scale)Assessment tool for behavior inhibition system and behavior activation system. Total test time : 15 mins. 8) FAB(Frontal assessment battery)Screening test for frontal function. Total test time : 5 mins. 9) FOG-Q(Freezing of Gait questionnaire)Assessment test for gait freezing. Total test time:1 to 2 mins. 10) SED-11Q(Symptoms of Early Dementia 11 Questionnaire)Questionnaire for screening dementia and awareness of having dementia. Total test time:5 mins. 11) Forgiveness scale: Assessment tool for tendency to foregive. Total test time : 15 mins. 12) SF-MPQ(Short Form McGill Pain Questionnaire)Self rating scale for pain. Total test time : 5 mins 13) Noise pareidoria test: Screening and assessment tool for visual hallucination. Total test time : 5 mins. 14) Overactive Bladder Symptom Score: OABSS. Self reported questionnaire for urinary symptoms. Total test time:5 mins. 15) Parkinson's disease sleep scale 2:PDSS 2. Self reported questionnaire for sleping condition for the past 7 days. Total test time:5 mins. Head MRI | — |
Contacts
Public ContactShigeki Hirano
Chiba University Hospital
Outcome results
None listed