Elective cardiac surgery requiring cardiopulmonary bypass valvular diseases, Ischemic heart diseases
Conditions
Interventions
Insulin, intranasal administration,perioperative
Sponsors
Nakadate Yosuke
Department fund (Department of Anesthesiology, University of Tsukuba)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients undergoing elective cardiac surgery requiring cardiopulmonary bypass 2) Patients who are 65 years old or older 3) Patietns who had not undergone nasal surgery 4) Patiets who provide signed informed consent to participate in the registry
Exclusion criteria
Exclusion criteria: 1) Patietns with preoperative delirium 2) Patients whose preoperative MMSE examination is 23 or less 3) Patients undergone cardiac surgery under hypothermia (< 32 degree celcius) condition 4) Patients with insulin allergy 5) Patietns with severe phycological disorder 6) Patients with severe neurological disorder 7) Patietns with severe hearing and/or visual impairment 8) Patients with Japanese language disability 9) Patients who are judged inappropriate by researchers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delirium within 7 days after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Days of postoperative delirium 2) Number of postoperative delirium 3) Change in MMSE-J score at 7days after surgery compared to before surgery 4) Change in MoCA-J score at 7days after surgery compared to before surgery 5) Postoperative pain score (Numerical rating scale) 6) Postoperative tracheal intubation time 7) Length of intensive care unit stay 8) Incidence of hypoglycemia 9) Incidence of postoperataive renal 10) Incidence of postoperative heart failure 11) Incidence of postoperative infection 12) Incidence of atrial fibrillation 13) Postoperative 7-day mortality rate 14) Incidence of all of adverse events | — |
Contacts
Public ContactYosuke Nakadate
University of Tsukuba Hospital
Outcome results
None listed