pollen-food allergy syndrome
Conditions
Interventions
Administer birch pollen-galactomannan conjugate
Sponsors
Komatsuzaki Keiko
Miyazaki Yasunari
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients who are positive for alder or white birch-specific IgE and exhibit oral allergy symptoms due to raw apples 2) Age between 18 and 64 at the time of obtaining consent 3) Subjects who have obtained written informed consent of their own free will after sufficient understanding to participate in this research. 4) Those who can go to Tokyo Medical and Dental University Hospital / Ikebukuro Otani Clinic
Exclusion criteria
Exclusion criteria: 1)Patients with a history of anaphylaxis to raw apples 2)Patients who have undergone allergen immunotherapy with Betulaceae pollen in the past 3) Subjects who performed a skin prick test with birch pollen-galactomannan conjugate ointment before the start and compared with the positive control, the wheal diameter was 1/2 or more or 3 mm or more larger than the wheal diameter of the negative control. 4) Patients who have undergone or are undergoing treatment with biological agents such as anti-IgE antibody, anti-IL-5 antibody, anti-IL-4a antibody, anti-TSLP antibody 5)Patients with suspected infectious disease within 4 weeks before enrollment 6) Patients with allergic rhinitis-like diseases such as acute rhinitis, suspected acute/chronic sinusitis, and eosinophilic sinusitis 7)Patients who received treatment with non-topical steroids or immunosuppressants within 4 weeks before enrollment 8) Patients with uncontrolled bronchial asthma, patients undergoing treatment or follow-up for malignant disease 9) Women who are pregnant or may become pregnant 10) Lactating women 11) Patients participating in other clinical trials or clinical studies at the time of enrollment 12) In addition, patients who are judged inappropriate by the principal investigator or researcher to conduct this research safely
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Raw apple oral challenge intake threshold and VASmm Wheal diameter of skin prick test with raw apple and birch extract | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary efficacy endpoints Serum birch-specific IgE, IgG, IgG1, IgG4, serum Bet v 1-specific IgE, IgG, IgG4 Saliva birch-specific IgA, IgG, serum and saliva TGF-b and IL-10 Total IgE, peripheral blood eosinophil count Nasal eosinophil count | — |
Contacts
Public ContactKeiko Komatsuzaki
Institute of Science Tokyo
Outcome results
None listed