Sever atrophic gastritis after Hp eradicaiton Sever atrophic gastritis, Hp eradicaiton
Conditions
Interventions
Probiotics (Lactobachillus gasseri/OLL2716) are administered for 6 months after 2nd upper endoscopy
Probiotics
Sponsors
Suzuki Takayoshi
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patient aged 18 years old and older 2. Patients with severe atrophy (O-2 or higher by Kimura/Takemoto classification) or a history of endoscopic treatment for early differentiated gastric cancer, in which H. pylori was likely involved in carcinogenesis 3. Patient who had Hp eradication history more than 6 months ago 4. Patient who have been fully informed and have given written consent to participate in this study
Exclusion criteria
Exclusion criteria: 1.Patient who is Hp positive 2.Patient who underwent gastric surgery 3.Patient who is unable to discontinue acid suppressants or probiotics other than LG21 during the study period 4. Patients with a history of food allergy to dairy products 5. A person who is determined to be inappropriate by the principal investigator or subinvestigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Degree of improvement in gastric mucosal inflammation findings before and after taking probiotics, obtained at the 2nd and the 4th exam each. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Pepsinogen I and Pepsinogen II 2. CRP 3. pH of gastric juice, LPS activity in the stomach 4. gastric flora | — |
Contacts
Public ContactJunko Nagata
Tokai University Hachioji Hospital
Outcome results
None listed