Effects of electrolyzed hydrogen water on ethanol intake mediated generation of acetaldehyde and following organ damages in healthy male volunteers

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs031220148

Enrollment

Registered

2022-06-20

Start date

2022-09-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

After the enrollment, the ALDH2 genotype will be examined two weeks before the start of the study to determine homozygosity and heterozygosity, and the loading test will be conducted in two sessions.

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1.Gender: Male 2.Age: 20 years old or older, under 65 years old 3.Those who enjoy moderate amounts of alcohol in their daily lives and whose weekly alcohol intake is 140g or less.

Exclusion criteria

Exclusion criteria: 1.Those with no drinking habits (less than once a week) 2.Those who have experienced health problems caused by alcohol in the past 3.Those who have started new medications or supplements within the last two months 4.Those suffering from chronic liver diseases (viral, autoimmune, drug-induced, metabolic, etc.) 5.Those taking medications or supplements that affect liver function (ursodeoxycholic acid, glutathione preparations, glycyrrhizin preparations, steroids, anti-hepatitis viruses, propagermanium, koshiba-goto, statins, EPA, DHA, vitamin C, vitamin E, sulforaphane Astaxanthin, liver hydrolysate, turmeric, curcumin, etc.) 6.Those who have ALT 40 IU/L or higher, AST 40 IU/L or higher, GTP 80 IU/L or higher, or total bilirubin 1.5 g/dl or higher 7.Patients with serious heart problems 8.Patients with poor renal function (serum creatinine > 2.0 mg/dL) 9.Those with cancerous conditions 10.Patients with acute or subacute disease at a level above suspicion 11.Those with symptoms such as fever, sore throat, cough, diarrhea, and vomiting 12.Persons who have participated in other human studies within 2 months prior to the start of the study 13.Those who have been drinking hydrogen water continuously before the start of the study. 14.Subjects whose ALDH2 genotype is *2/*2(R) [inactive type 15.Those who don't like shochu 16.Other persons deemed inappropriate by the principal investigator and the investigator in charge of the study

Design outcomes

Primary

Measure	Time frame
Blood:Acetaldehyde concentration, Blood alcohol concentration Urine:8OHdG production rate, Isoprostanes production rate, Indoxyl sulfate concentration, Pteridine concentration	—

Secondary

Measure	Time frame
AST, ALT, LDH, GTP, medical questionnaire	—

Contacts

Public ContactNoriaki Kishimoto

Tokai University Hospital

n-kissy@tokai.ac.jp+81-463-93-1121

Outcome results