Monkeypox Monkeypox
Conditions
Interventions
Vaccinate concentrated contacts of monkeypox with smallpox vaccine.
postexposure prophylaxis, smallpox vaccine
Sponsors
Mugen Ujiie
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Persons who have given written consent to participate in the research, either in person or by proxy. 2)Men and women who are at least one year of age at the time consent is obtained 3)Persons who have been in close contact with a person who has been diagnosed with monkeypox within 14 days 4) Persons who have not developed monkeypox.
Exclusion criteria
Exclusion criteria: 1) Persons with diseases that are clearly abnormal in immune function 2) Persons using corticosteroids or immunosuppressive drugs (cyclosporine, tacrolimus, azathioprine, etc.) 3) Persons with an apparent history of anaphylaxis caused by components of the smallpox vaccine 4) Patients with apparent fever 5) Persons who are obviously suffering from a serious acute disease 6) Those who are obviously pregnant 7) Persons suffering from a spreading skin disease, which may be impaired by immunization. 8) Persons who are in an inappropriate condition to be immunized. 9) Persons who are judged by the principal investigator to be inappropriate for inclusion in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Onset of disease 21 days after intense contact | — |
Secondary
| Measure | Time frame |
|---|---|
| Percent severe, death, symptoms (fever, headache, lymphadenopathy), complications (secondary skin infection, bronchopneumonia, sepsis, encephalitis, keratitis) | — |
Contacts
Public ContactTerada-Hirashima Junko
Center for Clinical Sciences, the National Center for Global Health and Medicine
Outcome results
None listed