Hypotrophic Hypotrophic
Conditions
Interventions
arm Ninjinyoeito : Ninjinyoeito are orally administered 2 to 3 times a day for 12 weeks.
Sponsors
Asaoka Daisuke
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) 65 years old or older 2) Outpatients at our hospital who can walk on their own 3) Poor nutritional status with CONUT score more than mild and MNA less than 24 points 4) Anorexia who score 14 or below on the SNAQ 5) Written informed consent
Exclusion criteria
Exclusion criteria: 1) Surgical resection of the stomach, gall bladder, small intestine, or large intestine except for appendicitis 2) Obese 3) Celiac disease, inflammatory bowel disease (Crohn's disease or ulcerative colitis), or ischemic colitis 4) Infectious enteritis 5) Mechanical obstruction, giant colon, or giant rectum 6) Malignant tumor of the digestive system except for cured by endoscopic surgery 7) Serious cardiovascular, respiratory, renal, hepatic, digestive, hematological, neurological, or psychiatric diseases except for sleeping pills only for insomnia. 8) Parkinson's disease 9) Hyperthyroidism or hypothyroidism 10) Participated in clinical trials, post-marketing clinical trials, or clinical research for other ethical drugs or medical devices within 3 months prior to obtaining consent. 11) Abusing alcohol and drugs 12) Allergy caused by herbal medicines, including Chinese herbal preparations 13) Regularly using other Chinese herbal preparations 14) Aldosteronism, myopathy, or hypokalemia 15) Inappropriate for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amount of change in CONUT score from baseline at 12 weeks of treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Rate of change in CONUT 2) Amount of change in SNAQ 3) Amount of in GNRI 4) Amount of change in serum albumin 5) Amount of change in prealbumin 6) Amount of change in body weight 7) Amount of change in BMI 8) Amount of change in Izumo scale 9) Amount of change in EAT-10 | — |
Contacts
Public ContactDaisuke Asaoka
Juntendo Tokyo Koto Geriatric Medical Center
Outcome results
None listed