Parkinson's disease Parkinson's disease
Conditions
Interventions
Single intravenous administration of [11C]K-2, which radiation dose should be around 370 MBq (330-407 MBq)
Sponsors
Abe Hiroki
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. 40 years old older and younger than 81 years old at the registration 2. Diagnosed as clinically established Parkinson's disease with MDS PD criteria 2015. 3. Underwent DAT SPETC within a year. 4. Patients who can express intents to participate in this research with written documents. A person who decides to participate in this research at his / her own free will can obtain written consent. However, when the consent explanation document cannot be read or written by the disease's symptoms, a witness will give his/her written consent. The witnesses are adults who are not unduly affected by those involved in this study and can take a third-party position. When he/she can not provide informed consent, it is possible to provide written consent with the substitute person's signature. A substitute person is an adult who is equivalent to his / her spouse, parents, compatriots, children, family members living together, or close relatives and can represent the will and interests.
Exclusion criteria
Exclusion criteria: 1. Patients who can not anwser their name, birth date or current month. 2. Patients who have a history of epilepsy. 3. Patients with dyalysis. 4. Patients who can not undergo head 3T-MRI. 5. Patietnts who underwent non-invasive brain stimulation therapy within a year. 6. Patients who have symptoms which could not be explained by PD.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SUVR (reference domains ; white matter) in right and left striatum dSUVRstr; striatum SUVR in higher SBR in DAT SPECT ndSUVRstrl; striatum SUVR in lower SBR in DAT SPECT | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. dSUVRstr and MDS-UPDRS part3 2. ndSUVRstr and MDS-UPDRS part3 3. dSUVRstr and MDS-UPDRS part3 lower items. 4. nd SUVRstr and MDS-UPDRS part3 lower items. 5. dSUVRstr minus ndSUVRstr and MDS-UPDRS part3. 6. dSUVRstr minus ndSUVRstr and MDS-UPDRS part3 lower items. 7. SUVR (reference domains ; white matter) computed in voxels in whole brain and MDS-UPDRS part3 8. SUVR (reference domains ; white matter) computed in voxels in whole brain and MDS-UPDRS part3 lower items. 9. SUVR (reference domains ; white matter) computed in voxels in whole brain and MoCA-J 10. SUVR (reference domains ; whole brain) computed in voxels in whole brain and MDS-UPDRS part3 11. SUVR (reference domains ; whole brain) computed in voxels in whole brain and MDS-UPDRS part3 lower items. 12. SUVR (reference domains ; whole brain) computed in voxels in whole brain and MoCA-J 13. MDS-UPDRS part1, 2 and total score of MDS-UPDRS. | — |
Contacts
Public ContactHiroki Abe
Yokohama City University Hospital
Outcome results
None listed