Skip to content

Effects of olfactory stimulation by L-menthol on dyspnea on exertion in chronic lung disease: A pilot study

Effects of olfactory stimulation by L-menthol on dyspnea on exertion in chronic lung disease: A pilot study

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
JPRN
Registry ID
JPRN-jRCTs031200400
Enrollment
34
Registered
2021-03-05
Start date
2021-04-14
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic obstructive pulmonary disease, Idiopathic interstitial pneumonias chronic respiratory failure

Interventions

Aroma seals coated with L-menthol are applied to a surgical mask and the mask is worn for a walking test.

Sponsors

Sakao Seiichiro
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) Patients with COPD or IIPs who are attending a respiratory medicine in our hosuital 2) Patients who are 20 years of age or older at the time of obtaining consent 3) Patients who are able to walk independently 4) Patients who can accurately perform respiratory function tests and 6MWT 5) Patients whose condition is stable and who have not changed their treatment for more than three months 6) Patients who have been fully informed of the contents of this study and have given written consent 7) Patients who are in or have completed an outpatient rehabilitation program, have stable symptoms, and are not scheduled for an outpatient rehabilitation program during this study

Exclusion criteria

Exclusion criteria: 1) Patients with severe orthopedic or central nervous system disease who need assistance with daily living 2) Patients who have been hospitalized for an exacerbation of an primary disease within the past six months 3) Patients with unstable cardiac disease 4) Patients with a history of other serious lung diseases such as occupational lung, sarcoidosis, airway hypersensitivity, malignant diseases, or lung infections caused by immunodeficiency 5) Patients with nasal obstruction and olfactory disturbances 6) Patients who are judged by the principal investigator/assistant physician to have a risk of compromising patient safety or to have difficulty complying with the protocol

Design outcomes

Primary

MeasureTime frame
modified Borg Scale before and after 6-minute walking test

Secondary

MeasureTime frame
SpO2 (before and after 6MWT) Pulse rate (before and after 6MWT) 6 minute walking distance St. George`s Respiratory Questionnaire (SGRQ) Steps/day Nagasaki University Respiratory ADL Questionnaire (NRADL) Quadriceps force Grip force Respiratory muscle force (PImax/PEmax) pulmonary function Dyspnea Language Questionnaire Multidimensional Dyspnea Profile Adverse event

Contacts

Public ContactTakeshi Inagaki

Chiba Prefectual University of Health Sciences

takeshi.inagaki_19@cpuhs.ac.jp+81-43-305-2184

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026