Aspirin-induced small bowel injuries Aspirin-induced small bowel injuries
Conditions
Interventions
Probiotics (Lactobacillus gasseri/OLL2716) are administered for 6 weeks to the control group, the proton pump inhibitor oral administration group, and the aspirin and proton pump inhibitor oral admini
Probiotic
Sponsors
Suzuki Takayoshi
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Older than 20 y.o. 2) Patients who plan to have a colonoscopy 3) Patients who gave written informed consent before entry in this study
Exclusion criteria
Exclusion criteria: 1) Patients who received antibiotics within 6 months before registration 2) Patients who regularly use other lactic acid bacteria preparations 3) Patients allergic to dairy products 4) A person who is determined to be inappropriate by the research director or co-workers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intestinal bacterial profile in the stool | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)Tight junction damage 2)COX expression 3)Amounts of mucosal prostaglandins 4)Existence ratio of immune cells 5)Intestinal bacterial profile (wash, biopsy tissue) 6)Amounts of calprotectin in the stool | — |
Contacts
Public ContactJunko Nagata
Tokai University Hachioji Hospital
Outcome results
None listed