Acute aortic dissection Acute aortic dissection
Conditions
Interventions
Inhale a mixed gas of oxygen and hydrogen for 8 hours a day for 3 days
Sponsors
Kawata Mitsuhiro
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. 40 years or older at the time of consent 2. Patients diagnosed with Stanford type B due to acute aortic dissection 3. Patients who can perform hydrogen gas inhalation therapy within 24 hours after entering the intensive care unit 4. Patients who understand the content of this study and can obtain written consent from the patient
Exclusion criteria
Exclusion criteria: 1. Patients with traumatic aortic dissection 2. Patients with rupture due to acute aortic dissection or scheduled for emergency surgery including stent graft 3. Patients suspected of having a bacterial infection, such as elevated procalcitonin levels before the start of hydrogen gas inhalation therapy 4.Patients clinically suspected of having a fungal infection before the onset of acute aortic dissection. (Whether or not there is a suspicion of a fungal infection will be determined by the attending physician based on clinical symptoms before the start of hydrogen inhalation. In addition, based on the results of beta-D-glucan before the start, cases with strong suspicion of fungal infection should be discontinued immediately after diagnosis.) 5. Patients with severe liver dysfunction equivalent to Grade C in the Child-Pugh classification 6. Patients with renal dysfunction requiring dialysis 7. Patients taking immunosuppressive drugs 8. Patients who have started or will start ventilator or ECMO 9. Patients with or suspected of having lung disorders (pneumonitis, COPD) 10.Patients with poor respiratory function who require 50 percent or more FiO2 to maintain PaO2. (Reservoir mask 15 L per min with FiO2 50 percent, PaO2 less than 60 mmHg) 11. Patients with or suspected of having cancer 12. Other patients who the investigator has determined to be ineligible for this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of related adverse events from the start of hydrogen administration to 4 days | — |
Secondary
| Measure | Time frame |
|---|---|
| AaDO2, PaO2, PaCO2, respiratory rate, P / F ratio, CRP, WBC value, body temperature, oxygen therapy required period | — |
Contacts
Public ContactMami Yoshioka
Tokyo Metropolitan Geriatric Medical Center
Outcome results
None listed