The blood concentration of acetaminophenin and analgesic effect

The relationship between the blood concentration after administration of intravenous acetaminophen and the onset of analgesia for healthy adults

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs031200321

Enrollment

Registered

2021-01-21

Start date

2021-01-21

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post operative pain acetaminophen, predicted cerebrospinal fluid concentration, pain threshold

Interventions

Intravenous administration of acetaminophen or physiological saline

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Volunteers who understand about this study and give informed consent with free will

Exclusion criteria

Exclusion criteria: 1) Patients who use cardiac pacemaker device 2) Expectant or nursing mothers 3) Patients who have severe hepatic impairment 4) Patients who have allergy to acetaminophen 5) Patients who have peptic ulcer 6) Patients who have hematological disorder 7) Patients who have severe kidney impairment 8) Patients who have severe cardiac dysfunction 9) Patients who have aspirin asthma 10)Patients who is judged ineligible by the doctor in charge

Design outcomes

Primary

Measure	Time frame
minimum perceived current,pain response current, blood concentration of acetaminophen	—

Secondary

Measure	Time frame
predicted cerebrospinal fluid concentration of acetaminophen, adverse effects	—

Contacts

Public ContactAkiko Nishimura

Showa University Dental hospital

nishim@dent.showa-u.ac.jp+81-3-3787-1151

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026