Anorexia in dementia with apathy Dementia/Anorexia/Apathy
Conditions
Interventions
Ninjin'yoeito administered three times daily (3.0 g each, 9.0 g / day) during the 12-week treatment period.
Sponsors
Arai Tetsuaki
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Alzheimer type dementia, Dementia with Lewy Bodies or Dementia associated with Parkinson's disease 2. MMSE less than 23 3. Neuropsychiatric Inventory subcategory scores for apathy 1 point or above 4. Neuropsychiatric Inventory subquestion scores for a loss of appetite 3 points or above 5. Treatment has been kept for psychotropic, antiulcer, estrogen, ACEI and zinc compound 6. Treatment has been kept for donepezil, galantamine, rivastigmine, memantine, antipsychotic, antiparkinson and steroid. 7. Agreement to sign an informed consent from patient, legal representative, study partner. Have a study partner able to provide an independent evaluation of functioning 8. Location; outpatient, inpatient, has been kept. 9. A patient who is able to take oral medications. 10. A patient who was informed dementia.
Exclusion criteria
Exclusion criteria: 1) Complications that may affect cognitive function. 2) Severe agitation/aggression 3) Major depression or bipolar disorder within the previous a year. Alcoholism within the previous 2 years, history of drug addiction, Vitamin B12 deficiency, folate deficiency, syphilis or thyroid disorders. 4) Digestive disorders 5) Patients with a life-threatening disease such as malignant tumor 6) Use of prohibited medication (prokinetic agent, stomachics and digestives, some kampo) within the previous 4 weeks 7) Participation in other studies within the previous 12 weeks. 8) Allergic to kampo 9) Pseudohyperaldosteronism 10) Potassium value is less than 3.0mEq / L 11) A patient who is not able to take kampo because of dysphagia. 12) Remarkable hypertension, edema 13) Heart failure, Kidney failure, Decompensated cirrhosis 14) A patient who takes glycyrrhizin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anorexia at 12 weeks compared to baseline (NPI score) | — |
Secondary
| Measure | Time frame |
|---|---|
| Total score of NPI Subscale of NPI Food intake Vitality Index MMSE,FAB Weight, Anemia, CONUT, Albumin | — |
Contacts
Public ContactMasashi Tamura
University of Tsukuba Hospital
Outcome results
None listed