Schizophrenia Schizophrenia
Conditions
Interventions
Administer sodium benzoate (2 g / day) and obs erve for 6 weeks.
Sponsors
Iwata Yusuke
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) DSM-V diagnosis of schizophrenia or schizoaffective disorder. 2) Age 18 to 65 years. 3) History of failure (score of 4 or more on 2 PANSS positive symptom items and CGI-Severity score of 4 or more) to respond to two or more different kinds of antipsychotics, each attaining a chlorpromazine daily dose of 400 mg or more for a duration 4 or more consecutive weeks. 4) On the same antipsychotic in the last 4 weeks before the inclusion. 5) Subject who provided written informed consent for research.
Exclusion criteria
Exclusion criteria: 1) Substance abuse or dependence (within past six months), excluding nicotine and caffeine. 2) Metal implants or a pace-maker that would preclude the MRI scan. 3) History of head trauma resulting in loss of consciousness > 30 minutes that required medical attention. 4) Unstable physical illness or significant neurological disorder including a seizure disorder. 5) Refusal to give consent to investigator to communicate with physician of record for the entire duration of the study. 6) Psychiatric concerns raised by the physician of record regarding participation in the study. 7) Currently taking clozapine 8) Currently taking medications that may directly impact the glutamatergic system (i.e. lamotrigine, topiramate, memantine)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in the brain glutamate and glutathione levels before and after sodium benzoate administration. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Correlation between glutamate and glutathion e concentrations in the brain and the total points of "Positive and Negative Syndrome Scale (PANSS)" at the baseline and 6 weeks after administarati on 2) Correlation between glutamate and glutathion e concentrations in the brain at the baseline and t he total points of "Positive and Negative Syndrom e Scale (PANSS)" 3) Changes in the glutamate levels in the blood after 6 weeks of sodium benzoate intake | — |
Contacts
Public ContactYusuke Iwata
Yamanshi University Hospital
Outcome results
None listed