Obstructive sleep apnea OSA AHI
Conditions
Interventions
Take atomoxetine and oxybutynin 30 minutes before falling asleep and perform PSG test
Sponsors
Sakao Seiichiro
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with OSA who have a treatment history or are undergoing treatment for OSA 2. Patients aged between 20 and 70 years 3. Written informed consent
Exclusion criteria
Exclusion criteria: 1. Patients with central apnea superior to obstructive apnea 2. Patients with drug allergy to atomoxetine and oxybutynin 3. Patients with severe liver function, cardiac function, renal function, pulmonary function disorder 4. Patients with severe central nervous system disease 5. Patients with bipolar disorder or psychotic disorder 6. Patients who have already taken MAO inhibitors or drugs equivalent to atomoxetine or oxybutynin 7. Pregnant women 8. Lactating women 9. Patients who are difficult to keep supine position during sleep 10. Patients who have a history of angle-closure glaucoma, history of paralytic ileus, history of pheochromocytoma, history of benign prostatic hyperplasia, history of urinary retention, history of myasthenia gravis 11. Patients with severe hyperthyroidism, ulcerative colitis, tachyarrhythmia, prolonged QT syndrome, seizures, cerebrovascular disorder 12. Patients judged to be ineligible
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in average value of AHI | — |
Secondary
| Measure | Time frame |
|---|---|
| SpO2 minimum difference, SpO2 drop time difference, Differences in sleeping stage | — |
Contacts
Public ContactSeiichiro Sakao
Chiba university hospital
Outcome results
None listed