Long-term intervention study of bone density maintenance and lifestyle-related disease prevention by daily lemon intake in Japanese men and women who lives in Osaki-Kamijima, Hiroshima

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs031200031

Enrollment

541

Registered

2020-05-19

Start date

2020-05-19

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None

Interventions

Lemon intervention group: Take one lemon a day (30 ml for lemon juice) Lemon non-intervention group: Take a normal diet

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Participants who have received a sufficient explanation of the purpose and contents of this test, have sufficient consent ability, have a thorough understanding, apply voluntarily, and have agreed to participate in writing. 2. Japanese adults over the age of 20 3. Participants who live in Osaki Kamijima Town, Hiroshima Prefecture

Exclusion criteria

Exclusion criteria: 1. Participants with a history of serious illness 2. Participants who have allergic to the test food 3. Participants who judged by the investigator to be inappropriate as subjects

Design outcomes

Primary

Measure	Time frame
Bone density (assessed by dual-energy X-ray absorptiometry)	—

Secondary

Measure	Time frame
Blood tests: (Red blood cell count, hemoglobin, hematocrit, total protein, albumin, total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, AST, ALT, ALP, gamma-GTP, CPK, creatinine, uric acid, glucose, HbA1c (NGSP), osteocalcin (BGP), bone tartrate-resistant acid phosphatase (TRACP-5b), bone alkaline phosphatase (BAP)) Urinalysis: (glucose, protein, sodium, creatinine, salt intake volume) Physical measurements: (sleep, weight, BMI, blood pressure, pulse, abdominal circumference) Questionnaire survey: (Basic survey on sleep, fatigue, lemon intake record, diet, medical history, dispensing information, etc.)	—

Measure

Time frame

Blood tests: (Red blood cell count, hemoglobin, hematocrit, total protein, albumin, total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, AST, ALT, ALP, gamma-GTP, CPK, creatinine, uric acid, glucose, HbA1c (NGSP), osteocalcin (BGP), bone tartrate-resistant acid phosphatase (TRACP-5b), bone alkaline phosphatase (BAP)) Urinalysis: (glucose, protein, sodium, creatinine, salt intake volume) Physical measurements: (sleep, weight, BMI, blood pressure, pulse, abdominal circumference) Questionnaire survey: (Basic survey on sleep, fatigue, lemon intake record, diet, medical history, dispensing information, etc.)

—

Contacts

Public ContactJunichi Tsuchiya

POKKA SAPPORO Food & Beverage Ltd.

junichi.tsuchiya@pokkasapporo-fb.co.jp+81-3-5795-1201

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026