type 2 diabetes mellitus
Conditions
Interventions
For breakfast, subjects ingest 150g of OIST rice or white rice on separate days after overnight fast. Each test day has an interval of 1-3 days.
Sponsors
Nakamura Yuta
NICHIREI CORPORATION
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who are admitted to the Department of Metabolism and Endocrinology, St. Marianna University Hospital for improvement of glycemic control and meet the following criteria. 1. Patients with insulin-independent type 2 diabetes mellitus ; fasting serum C-peptide>=0.6 ng/ml and GAD antibody negative. 2. Patients with a fasting blood glucose level of 54-300 mg/dL during the last 3 days. 3. Male or female over the age of 20 at the time of obtaining informed consent. 4. Patients who agreed to use the data of urine and blood tests ; Hgb, Hct, blood glucose, AST, ALT, Cre, BUN, UA, T-chol, HDL-chol, LDL-chol, TG, HbA1c, GA, C-peptide, urinary microalbumin. 5. Patients with written informed consent after receiving a full explanation.
Exclusion criteria
Exclusion criteria: 1.Patients using any of the following diabetes treatments. /DPP4 inhibitor /GLP-1 receptor agonist /alpha-glucosidase inhibitor 2.Patients who need more than 15 units of rapid-acting insulin in the morning when obtaining informed consent. 3.Patients with unstable oral intake. 4.Women who were pregnant, possibly pregnant, or were breastfeeding. 5.Menstrual period. 6.Rice allergy or brown rice allergy. 7.Patients who were considered to be ineligible for other reasons by the attending doctor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| total AUC0-240min - glucose | — |
Secondary
| Measure | Time frame |
|---|---|
| incremental AUC0-240min - glucose total AUC0-240min - insulin incremental AUC0-240min - insulin total AUC0-240min - total GLP-1 incremental AUC0-240min - total GLP-1 total AUC0-240min - total GIP incremental AUC0-240min - total GIPpreference questionnaire | — |
Contacts
Public ContactYuki Ohta
St. Marianna University School of Medicine
Outcome results
None listed