status epilepticus status epilepticus
Conditions
Interventions
At first, diazepam 1 - 20 mg is given in both groups.
Hosphenytoin group
After diazepam, hosphenytoin 22.5mg/kg+normal saline 100ml is given DIV by under 3mg/kg/min or 150mg/min
Levetiracetam group
A
levetiracetam
Sponsors
Inoue Yoshiaki
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: status epilepticus with convulsion, who were transfered by ambulance The difinition of status epilepticus is as follows; over 5 minutes of continuous seizures, or over 2 minutes discrete seizures between which there is incomplete recovery of consciousness over JCS II-30 exclude non-convulsive seizure
Exclusion criteria
Exclusion criteria: under 20 years old patients who entried this study in the past patients in whom informed consent can not be obtained from proxies (If proxies can not be found, the study is performed and the consent is obtained after action. already intubated patients before treatment allergy to fosphenytoin or levetiracetam pregnancy pseudo-seizure medical doctor considered inapropriate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| seizure stop within 30 min from start of study drugs administration | — |
Secondary
| Measure | Time frame |
|---|---|
| seizure reccurence within 24 h severe adverse events intubation rate | — |
Contacts
Public ContactKensuke Nakamura
Hitachi General Hospital
Outcome results
None listed