Normal subjects
Conditions
Interventions
Positron emission tomography study using un-approved ligand [18F]MC225
Sponsors
Ishii Kenji
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: The following criteria must be met by ALL Subjects: 1. Male subjects aged between 20 and 60 years at the informed consent 2. Subjects who provide written informed consent.
Exclusion criteria
Exclusion criteria: Subjects who have any of the following present or past history of illness: 1. Past history of neuropsychiatric disorders such as epilepsy, major depression, or schizophrenia 2. Subjects who are currently taking prescription drugs, general pharmaceuticals, quasi-drugs, and health food products (suppliments) 3. Smorkers 4. Subjects who drink alcohol the day before or the day of the visit 5. Subjects who have contraindication of or being inadicuate for MRI 6. Subjects who have past history of severe drug hypersensitivity 7. Subjects who have past history of cardiovascular diseases 8. Subjects who are currently suffering from chronic anemia, chronic renal failure, or any other significant diseases 9. Subjects who are judged as ineligible for the study by the principal investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Human radiation dosimetry of [18F]MC225 2. Safty of intravenous administration of [18F]MC225 3. Pharmakokinetics of [18F]MC225 (metabolism, blood clearance, urine extraction rate) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Optimization of data acquisition methods and scanning protocol 2. Establishment of quantification 3. Building appropriate methods for image evaluation and analysis | — |
Contacts
Public ContactMami Yoshioka
Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Outcome results
None listed