Postprandial hypotension Lewy body disease
Conditions
Interventions
Administration of Sitagloptin 25mg p.o. just after wakening up
Sponsors
Ishikawa Joji
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients with postrandial hypotension or orthostatic hypotension. 2) Blood glucose >=140 mg/dl within 2 hours from 75g glucose intake. 3) Patients with Lewy body disease (Parkinson disease or Dementia with Lewy body (DLB)), inculuding subjects with prodromal DLB diagnosed by indicator biomarkers (such as dopamine transporter scan and/or MIBG scintigraphy). 4) Patients under stable anti-parkinson disease medication for at least 3 months.
Exclusion criteria
Exclusion criteria: 1) Allergy to sitagliptin 2) Patients who are taking any anti-diabetic drugs 3) Severe renal disease (serum creatinine >= 2.5mg/dl for men, >=2.0mg/dl for women) 4) Severe hepatic disease 5) Pacemenker implantation 6) On hemodialysis 7) Pregnant women 8) Difficulty to take medication 9) Patients who are taking MAO inhibitor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Safety of sitagliptin administration Absense of severe hypoglycemic event during 3 months of sitagliptin administration | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Change in blood pressure reduction after in 75g oral glucose intake after administration of sidagliptin. 2) Change in postprandial hypotension in 24-hr ambulatory blood pressure monitorin. 2) Change in orthostatic hypotension in Head-up tilt test. 3) Change in symptoms or quality of life. 4) Change in CVRR in electrocardiogram. 5) Frequency of asymptomatic hypoglycemia (<70 mg/dl) | — |
Contacts
Public ContactMami Yoshioka
Tokyo Metropolitan Geariatric Hospital and Institute of Gerontology
Outcome results
None listed