maxillary sinus cancer maxillary sinus cancer, head and neck cancer
Conditions
Interventions
Patients with advanced maxillary sinus caner is treated by 4 to 7 times of weekly intra-arterial infusion of cisplatin (120mg/m2) and concurrent radiation therapy using 4-6 MV Linac X-ray of total dos
D010478
intraarterial chemotherapy, RADPLAT, cisplatin
Sponsors
Tanaka Norimitsu
Sone Miyuki
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Maxillary sinus cancer pathologically proved as squamous cell carcinoma 2.Maxillary sinus cancer staged as T3 and T4 on UICC, 2009. 3.No metastatic lymph node 4.Primary treatment case 5.Measurable disease 6.Cather accessible case into the feeding arteries, including internal maxillary artery, facial artery and transverse facial artery. 7.Pursuing of non-surgical and organ-preserving treatment, but salvage surgery for residual cancer can be done. 8.Age of the patient: >=20 y.o. and <=75 y.o. 9.Prognosis better than 8 months 10. ECOG Performance status (PS) 0 or 1
Exclusion criteria
Exclusion criteria: 1)Bone suppression state 2)Severe infection in the head and neck region 3)Severe systemic complication, such as intestinal paralysis, ileus, interstitial pneumonitis, pulmonary fibrosis, uncontrolled DM, heart failure, renal failure, and liver failure. 4)Synchronized active cancer 5)History of irradiation for head and neck region 6)History of allergy for cisplatin or contrast medium 7)Severe mental disorder 8)Pregnant, unwell to practice contraception during the study or lactating female 9)Preoperative therapy for planed surgery 10)Inaccessible catheterization due to arteriosclerosis 11)Other causes judged unpreferable by attending physician for this protocol treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Local control rate | — |
Secondary
| Measure | Time frame |
|---|---|
| Primary response, adverse events, 0ver all survival, Relapse-free survival | — |
Contacts
Public ContactNorimitsu Tanaka
Kurume University Hospital
Outcome results
None listed