Cervical cancer Cervical cancer
Conditions
Interventions
Concurrent chemoradiotherapy
Sponsors
Imai Yuichi
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Age 20 years or older. 2. Patient must have been pathologically diagnosed with squamous cell carcinoma, adenocarcinoma or adenosquamous carcinoma of the cervix. 3. Patients must have clinical stage III to IVA disease. 4. Patients must have renal dysfunction (less than 60 ml/min of eGFR). 5. Patients must not have previously received radiation therapy, chemotherapy or surgery for the current disease. 6. ECOG performance status must be 0 or 1. 7. Patients must have adequate organ functions except renal function. 8. Patients must have provided written informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with vaginal stump cancer. 2. Patients with active infectious disease. 3. Patients with severe complications: for example, uncontrolled hypertension, diabetes, active bleeding or collagen disease for which steroid therapy is required. 4. Patients who have received radiation therapy at the pelvis. 5. Patients who have received chemotherapy with paclitaxel or carboplatin. 6. Patients with any active concurrent malignancies. 7. Patients who need hemodialysis or peritoneal dialysis continuously. 8. Patients who are pregnant, may become pregnant, or hope to become pregnant. 9. Patients who are breast-feeding. 10. Patients considered to be inappropriate for any reason by their attending physicians.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Discontinuance rate (defined as the rate of patients which are unable to continue the protocol therapy for any adverse events) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.PFS 2.Completion rate (defined as the rate of performed chemo or radiation dosage prescribed in protocol within 8 weeks) 3.Overall response rate to the protocol therapy | — |
Contacts
Public ContactYuichi Imai
Yokohama City University Hospital
Outcome results
None listed