Physically and mentally healthy
Conditions
Sponsors
Okita Kyoji
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1.Physically and mentally healthy male nonsmokers aged between 20 and 65 (nonsmoker is defined as those who has not smoked for the last one year) 2.No problems with communication in Japanese language and understanding documents of informed consent
Exclusion criteria
Exclusion criteria: 1.Past history of neurological and/or psychiatric disorders 2.Intracranial lesion(s) seen in MRI 3.Impairment of liver and/or renal function 4.HIV seropositive 5.Positive urine-sample test for illegal drug 6.Past history of suicidal ideation or attempt 7.Claustrophobia or aichmophobia 8.MRI imcompatible metals inside the body 9.Use of psychotropic drugs which could have an impact on dopamine D2 receptor availability 10.Engaged in night work 11.Employees of National Center of Neurology and Psychiatry or any companies that have a business connection with National Center of Neurology and Psychiatry 12.Participate in any other clinical trials or studies 13.In case of principle investigator judges inappropriate to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Striatal dopamine D2 receptor availability | — |
Secondary
| Measure | Time frame |
|---|---|
| Neurocognitive measures relating impulsivity, eyelid movement (eyeblinks) and plasma concentration of istradefylline | — |
Contacts
Public ContactKaori Takeda
National Center of Neurology and Psychiatry
Outcome results
None listed