The development of new preventive measures and therapeutic methods in the management of hand-foot syndrome by regorafenib

The development of new preventive measures and therapeutic methods in the management of hand-foot syndrome by multi-kinase inhibitors regorafenib - PMTMHFS

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs031180096

Enrollment

Registered

2019-01-25

Start date

2019-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal cancer

Interventions

Effectiveness of prevention of hand-foot syndrome associated with Regorafenib by using aluminum chloride and wound dressing

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)Colorectal cancer patients who are scheduled to be on Regorafenib 2)Patients are scheduled to be administered the drugs at a dose of 120mg 3) PS0-1 4) Written informed consent for this study can be obtained from the patients.

Exclusion criteria

Exclusion criteria: 1) Patients with fissure or erosion in the palmoplantar area 2) Patients with a history of sympathectomy

Design outcomes

Primary

Measure	Time frame
Incidence of Grade 3 HFS	—

Secondary

Measure	Time frame
Incidence of hand-foot syndrome including all grades, duration until the initial presentation of hand-foot syndrome, duration until the presentaion of hand-foot syndrome with more than grade 2, duration between the presentation of hand-foot syndrome with more than grade 2 and the improvement in the symptoms with the grade decreased to grade 1 or 0, the incidence of cases with reducing the dose of Regorafenib due to hand-foot syndrome, incidence of drug withdrawal due to hand-foot syndrome, the incidence of cases with treatment withdrawal due to hand-foot syndrome, incidence of discontinue medication of regorafenib due to hand-foot syndrome, incidence of side effects by alminum chloride	—

Measure

Time frame

Incidence of hand-foot syndrome including all grades, duration until the initial presentation of hand-foot syndrome, duration until the presentaion of hand-foot syndrome with more than grade 2, duration between the presentation of hand-foot syndrome with more than grade 2 and the improvement in the symptoms with the grade decreased to grade 1 or 0, the incidence of cases with reducing the dose of Regorafenib due to hand-foot syndrome, incidence of drug withdrawal due to hand-foot syndrome, the incidence of cases with treatment withdrawal due to hand-foot syndrome, incidence of discontinue medication of regorafenib due to hand-foot syndrome, incidence of side effects by alminum chloride

—

Contacts

Public ContactAya Nishizawa

Japanese Foundation For Cancer Research

aya.nishizawa@jfcr.or.jp+81-3-3520-0111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026