Safety study of artificial neural connection in stroke

Study of safety of artificial neural connection using noninvasive spinal magnetic stimulation in stroke patients

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs022210049

Enrollment

Registered

2021-11-19

Start date

2022-12-09

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain infarction, hemorrhage

Interventions

Closed-loop, non-invasive, transvertebral magnetic stimulation triggered by an artificial neural connection

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Age: 20-80 (2) Under the agreement with written consent form (3) Diagnosed as stroke (brain infarction or hemorrhage) by a physician (4) Leg Brunstrom Statge VI or worse than IV including walking disability (5) Chronic phase after stroke onset

Exclusion criteria

Exclusion criteria: (1) Fit into following cases History of harmful sides effects due to magnetic or electrical stimulation, History of seizure or epilepsy including family members, Hisotry of febrile convulsion, Disease or injury of head, brain, spinal cord including brain surgery, Medical device imlantation such as cardiac pacemaker, neurosurgical clips, battery or pumps, non-titanium metal implants in the head or the stimuls target area of trunk, Prospect of pregnancy (2) Inappropriate patient decided by a physician, such as cardiovascular disorders (3) Current participation in clinical trials for an approved drug or clinical device (4) History of botulinum toxin therapy within 4 months

Design outcomes

Primary

Measure	Time frame
Safety application of artificial neural connection for 3 months	—

Secondary

Measure	Time frame
Safety application of artificial neural connection after 3 months, Objective sensation regarding the strength of transvertebral magnetic stimulation, Artificial neural connection induced walking, Voluntary walking, Motor evoked potential elicited by transcranial magnetic stimulation, Motor evoked potential elicited by transvertebral magnetic stimulation, Overground walking, Treadmill walking, Brunstrom test, Fugl-Meyer assessment, Modified Ashworth Scale, Magnetic resonance imaging	—

Measure

Time frame

Safety application of artificial neural connection after 3 months, Objective sensation regarding the strength of transvertebral magnetic stimulation, Artificial neural connection induced walking, Voluntary walking, Motor evoked potential elicited by transcranial magnetic stimulation, Motor evoked potential elicited by transvertebral magnetic stimulation, Overground walking, Treadmill walking, Brunstrom test, Fugl-Meyer assessment, Modified Ashworth Scale, Magnetic resonance imaging

—

Contacts

Public ContactTakashi Murayama

Chiba Rehabilitation Center

takashi.murayama@chiba-reha.jp+81-43-291-1831

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026