Comparison of MECHANISM of early and late vascular responses following treatment of ST-elevation Acute Myocardial Infarction with two different everolimus-eluting stents: Randomized controlled trial between biodegradable polymer and durable polymer stent

Comparison of MECHANISM of early and late vascular responses following treatment of ST-elevation Acute Myocardial Infarction with two different everolimus-eluting stents: Randomized controlled trial between biodegradable polymer and durable polymer stent - MECHANISM-AMI-RCT

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs022180024

Enrollment

120

Registered

2019-03-25

Start date

2018-11-08

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ST elevation acute myocardial infarction (STEMI)

Interventions

revascularization of culprit lesions of ST-elevation myocardial infarction with either bioabsorbable polymer-based everolimus-eluting stent or durable polymer-based everolimus-eluting stent (1:1 rando

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)Patients with ST-elevation acute myocardial infarction 2)Patients with existence of coronary culprit lesions that should be treated with drug-eluting stents 3)Patients with planned cardiac catheterization procedure after 2 weeks

Exclusion criteria

Exclusion criteria: 1)Hemodynamically shock 2)Culprit lesion of left main coronary artery 3)Chronic renal failure with serum creatinine levels = or > 2.0mg/dl(including hemodialysis) 4)Cancer patients with life prognosis shorter than 2 years or scheduled surgery within 3 months

Design outcomes

Primary

Measure	Time frame
Strut coverage rate evaluated by optical coherence tomography 2 weeks after stent implantation	—

Secondary

Measure	Time frame
Evaluation by optical coherence tomography at post-procedure, 2 weeks, 1 year 1) strut coverage rate 2) maximum area of in-stent thrombus 3) mal-apposition rates of struts 4) minimal limen area	—

Contacts

Public ContactKanako Omiya

Iwate Medical University Hospital

komiya@iwate-med.ac.jp+81-19-613-7111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026