type 2 diabetes mellitus, periodontitis type 2 diabetes mellitus, periodontitis
Conditions
Interventions
The principal investigator or co-investigator will obtain written consent to participate in the study and, based on the results of the screening test, will determine eligibility by confirming that the
Sponsors
Waki Hironori
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Men and women over 18 years old 2) Patients daignosed with type 2 diabetes 3) Patients with HbA1c of 7.0-10.0% 4) Patients who answered that they had oral symptoms in the Japanese version of the CDC/AAP questionnaire 5) Patients with a probing pocket depth of 4mm or more
Exclusion criteria
Exclusion criteria: 1) Systemic diseases that increase the risk of periodontal disease (e.g., leukemia, AIDS) 2) Smoking 3) Receiving immunosuppressants 4) Receiving steroids 5) Acute illness 6) Pregnancy or breastfeeding 7) Change in diabetes treatment within 10 weeks prior to the start of the study 8) Receiving antibiotics within 12 weeks prior to the start of the study 9) Dental treatment for periodontal disease within 12 weeks prior to the start of the study 10) Daily use of mouthwash 11) Fewer than 11 remaining teeth 12) Periapical lesion 13) Orthodontic treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in periodontitis indicators (probing pocket depth, gingival index) and glucose metabolism indicators (fasting blood glucose, glycoalbumin, TIR on CGM) before and after the self-care period at week 0 and week 4 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Changes in periodontitis indicators (high-sensitivity CRP, ADCHECK, OHRQL) and glucose metabolism indicators (HbA1c, insulin resistance index, CGM indicators) before and after the self-care period at week 0 and week 4 2) The relationship between changes in periodontitis indicators (probing pocket depth, gingival index, high-sensitivity CRP, ADCHECK) and changes in glucose metabolism indicators (fasting blood glucose, HbA1c, glycoalbumin, insulin resistance index, CGM index) during the self-care period from week 0 to week 4 3) Changes in periodontitis indicators (probing pocket depth, gingival index, high-sensitivity CRP, ADCHECK, OHRQL) and glucose metabolism indicators (fasting blood glucose, HbA1c, glycoalbumin, insulin resistance index, CGM index) before and after the self-care period at week 0 and week 4, stratified by self-care implementation rate 4) Changes in periodontitis indicators (probing pocket depth, gingival index, high-sensitivity CRP, ADCHECK, OHRQL) and glucose metabolism indicators (fasting blood glucose, HbA1c, glycoalbumin, insulin resistance index, CGM indices) before and after dental and oral surgery periodontitis treatment at weeks 4 and 16 5) The relationship between changes in periodontitis indicators (probing pocket depth, gingival index, high-sensitivity CRP, ADCHECK) and changes in glucose metabolism indicators (fasting blood glucose, HbA1c, glycoalbumin, insulin resistance index, CGM indices) during dental and oral surgery periodontitis treatment from week 4 to week 16 6) Changes in periodontitis indicators (probing pocket depth, gingival index, high-sensitivity CRP, ADCHECK, OHRQL) and glucose metabolism indicators (fasting blood glucose, HbA1c, glycoalbumin, insulin resistance index, CGM index) before and after dental oral surgery periodontitis treatment at weeks 4 and 16, stratified by self-care implementation rate. 7) Changes in periodontitis indicators (probing pocket depth, gingival index, high-sensitivity CRP, ADCHECK, OHRQL) a | — |
Contacts
Public ContactHana Akanuma
Akita University Hospital
Outcome results
None listed