Healthy person
Conditions
Interventions
An oral glucose load of 75.5 g is administered early in the morning on an empty stomach: 150 mL of a 50% glucose solution containing 75 g glucose (Otsuka Pharmaceutical) and 0.5 g 13C-labeled glucose
Sponsors
Sawada Shojiro
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Healthy male adult Between 20 and 65 years of age at the time consent is obtained Those understand the explanation of study participation and sign a written consent form
Exclusion criteria
Exclusion criteria: Those having diseases that affect glucose metabolism (diabetes, thyroid disease, liver dysfunction, renal dysfunction, under steroid treatment, cancer, etc.) Those suggestive of hypotonic dehydration (physical condition on the day of examination will be interviewed to determine whether there is fatigue, dry mouth, decreased urine output, or loss of electrolytes due to fever, diarrhea, vomiting, etc.) Body mass index (BMI) of 30 or higher At least 110 mg/dL measured with a simple blood glucose meter before this test Taking any medication Those who the investigator deems inappropriate for the subject of this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 13CO2 exhalation in exhaled breath | — |
Secondary
| Measure | Time frame |
|---|---|
| Association of 13CO2 expiratory excretion in breath with insulin secretory capacity (HOMA beta), insulin resistance (HOMA-IR), and hepatic insulin clearance (C-peptide/insulin ratio) | — |
Contacts
Public ContactShojiro Sawada
Tohoku Medical and Pharmaceutical University Hospital
Outcome results
None listed