Sentinel lymph node detection of the head and neck cancer by contrast-enhanced ultrasonography

Sentinel lymph node detection of the head and neck cancer patients by ultrasonography using micro-bubble contrast-medium -Phase I study of the efficacy of sonazoid targeting head and neck cancers-

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs021180036

Enrollment

Registered

2019-03-25

Start date

2015-12-15

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

head and neck cancer

Interventions

intra-venous injection of contrast-medium

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. head and neck cancer patients with untreated lymph node metastasis in the neck 2. patients with the tumor which will be resected and diagnosed by histopathological examination 3. patients more than 20 years old

Exclusion criteria

Exclusion criteria: 1. patients with allergy to egg or ingredient made from egg 2. patients with arterio-venous shunt in heart or lung 3. patients with severe heart disease 4. patients with severe lung disease 5. patients who will undergo laparoscopic examination or digestive tract examination using effervescent agent on the same day undergoing this examination 6. pregnant or possible pregnant patients and breast-feeding patients 7. patients who can not receive contrast-enhanced MRI or CT examination 8. patients whose target tumor are recurrent diseases 9. patients who received or will be received contrast-enhanced media (Iode media, MRI media, other contrast-enhanced media for ultrasonography etc.) during the day before and after the day of sonazoid injection 10. patients who responsible doctors recognize inappropriate for this study

Design outcomes

Primary

Measure	Time frame
Detection rate of sentinel lymph node by ultrasonography using contrast-medium	—

Contacts

Public ContactDaisuke Saito

Iwate Medical University

kshiga@iwate-med.ac.jp+81-19-613-7111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026