Interventions to improve reproductive outcomes in recurrent pregnancy loss with elevated natural killer cell activity

Interventions(immunoglobulin and intralipid) to improve reproductive outcomes in recurrent pregnancy loss or repeated implantation failure women with elevated natural killer cell activity - IVIG and intralipid trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs021180020

Enrollment

Registered

2019-03-25

Start date

2015-04-30

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Recurrent pregnancy loss and recurrent implantation failure

Interventions

Recurrent pregnancy loss: IVIG or intralipid given when the patient get pregnant. Recurrent implantation failure: IVIG or intralipid given at the day of embryo transfer.

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Recurrent pregnancy loss women with elevated natural killer cells activity. Recurrent implantation failure women with elevated natural killer cells activity.

Exclusion criteria

Exclusion criteria: None

Design outcomes

Primary

Measure	Time frame
pregnancy rate, live birth rate	—

Secondary

Measure	Time frame
adverse events	—

Contacts

Public ContactRIE FUKUHARA

Hirosaki University Hosipital

fukuhara@hirosaki-u.ac.jp+81-172-39-5107

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026