Normal pressure hydrocephalus, Alzheimers disease, other dementia, or mild cognitive impairment
Conditions
Interventions
Intrathecal injection of PSO17.
Sponsors
Kudo Kohsuke
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Patients who admitted Hokkaido University Hospital (department of neurolog y or psychiatry), and suspected of normal pressure hydrocephalus, Alzheimer's disease, other dementia, or minor cognitive impairment. (2) The patients is scheduled to be performed intrathecal needle insertion (for CSF exam or tap test). (3) Over 20 years old when informed consent is obtained. (4) Written informed consent is obtained after sufficient explanation and full understanding
Exclusion criteria
Exclusion criteria: (1) Contraindication for MRI such as metallic implant (excluding MRI conditional devises), tatoo in the upper body, or claustrophobia. (2) Severe lumbar canal stenosis. (3) Other psychiatric diseases. (4) Pregnant, suspected pregnancy, plan for pregnancy, refusing contraception including partner, or breast beeding. (5) Other reason for inadequacy to admit this study judged by principal investigator or co-investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| safety | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of dynamic changes in O17 concentration measured by MRI signals of CSF. | — |
Contacts
Public ContactKohsuke Kudo
Graduate school of medicine, Hokkaido University
Outcome results
None listed