Alveolar bone regeneration with fresh isolated adipose stem/progenitor cells

Alveolar bone regeneration with non-cultured autologous adipose tissue-derived stem/progenitor cells -Phase I clinical study- - Bone regeneration with ADSCs

Status

Active, not recruiting

Phases

Phase 1

Study type

Unknown

Source

JPRN

Registry ID

JPRN-jRCTb070190059

Enrollment

Registered

2020-03-31

Start date

2018-02-21

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe alveolar bone atrophy

Interventions

1x10^7 non-cultured fresh isolated adipose cells are mixed to TCP and rhBMP2 as implants.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients who are partially or fully edentulous, and are required to treat by dental implants for prosthetic rehabilitation. 2. Patients who have insufficient bone height and/or width to place the dental implant 3. Patients who received the oral health care and maintain the good condition of Plaque Control. 4. The age of the patients: 20- to 70-years old

Exclusion criteria

Exclusion criteria: 1. All patients are required to be nonsmokers. 2. Patients who have systemic disease, malignances, chronic infections, immune system abnormalities, septicemia, syphilis, HBV, HCV, HTLV-1, HIV, pregnancy, dementia. 3. Patients who have disorder of blood coagulation. 4. Patients who have hepatitis function disorders, metabolic bone disease or skeletal dysplasia. 5. Patients who needs the legal representative.

Design outcomes

Primary

Measure	Time frame
Safety	—

Secondary

Measure	Time frame
Analyses of new bone formation by bone biopsy and CT imaging.	—

Countries

Japan

Contacts

Public ContactYoshinori Sumita

Nagasaki University

y-sumita@nagasaki-u.ac.jp+81-95-819-7706

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026