A case with esophageal stricture after ESD treatment for early esophageal cancer
Conditions
Interventions
Oral mucosa and peripheral blood are collected from the patient, and an oral mucosal epithelial cell sheet is prepared from the collected oral mucosa and peripheral blood. The prepared cell sheet is t
Sponsors
ATSUNAGA KATOU
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients aged 20 years or older. 2) Patients with esophageal stenosis that occurred after ESD treatment for early esophageal cancer. 3) Patients whose main organ function is kept as a rule as below (data within 1 month before registration). Leukocyte count >= 4,000 = 100,000 Serum AST (GOT) and ALT (GPT) <= 100 Serum total bilirubin <= 2.0 Serum creatinine <= 2.0 In the above, the inspection standard value of the currently practiced esophageal regeneration cell sheet trial was adopted. However, if it is considered that the reason for not satisfying the above is based on the original disease, it can be selected according to the judgment of the research representative.
Exclusion criteria
Exclusion criteria: 1) Patients with complications of poor control (Heart disease, liver disease, kidney disease, cerebral infarction, etc.). 2)Patients with pregnancy, lactating women and possibility (intention) of pregnancy. 3)A patient with a history of serious drug allergy. 4)Patients infected with infectious diseases (hepatitis B, hepatitis C, HIV, HTLV-1, syphilis). 5)A patient who has a disease in the oral mucosa at the tissue collection site and is unable to collect it. 6)Other patients who are deemed inappropriate by the research representative.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Safety of oral mucosal epithelial cell sheet | — |
Secondary
| Measure | Time frame |
|---|---|
| Prevention of esophageal stricture by transplanting oral mucosal epithelial cell sheet | — |
Countries
Japan
Contacts
Public ContactOCHIAI ATSUSHI
Social Medical Corporation Yuaikai Yuuai Medical Cetner
Outcome results
None listed