An Exploratory Study of CS-3150 to Evaluate the Relation between Antihypertensive Effect and Baseline Factors Compared to Olmesartan Medoxomil in Patients with Essential Hypertension

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT2080223269

Enrollment

Registered

2016-07-22

Start date

2016-08-03

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Essential hypertension

Interventions

investigational material(s) Generic name etc : CS-3150 INN of investigational material : Esaxerenone Therapeutic category code : 214 Antihypertensives Dosage and Administration for Investigational mat

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)Male and female subjects aged 20 years or older at informed consent 2) Subjects with essential hypertension during run-in period (mean 24 hr SBP >= 130 and DBP >= 80 mmHg , and Sitting SBP >= 140 mmHg and = 90 mmHg and < 110 mmHg)

Exclusion criteria

Exclusion criteria: 1)Secondary hypertension or malignant hypertension 2)Diabetes mellitus with albuminuria 3)Serum potassium level = 5.1 mEq/L 4)Reversed day-night life cycle including overnight workers 5)eGFR < 60 mL/min/1.73 m^2.

Design outcomes

Primary

Measure	Time frame
safety efficacy exploratory - Relationship between the change from baseline in 24 hr blood pressure (systolic, diastolic, and avarage blood pressure) and baseline factors. - Adverse events	—

Secondary

Measure	Time frame
efficacy -Relationship between the change from baseline in morning, evening, and night blood pressure (systolic, diastolic, and avarage blood pressure) and baseline factors. -Relationship between the change from baseline in sitting blood pressure (systolic and diastolic blood pressure) and baseline factors. -Change from baseline in sitting blood pressure (systolic and diastolic blood pressure) and baseline factors. -Time course of 24 hr blood pressure and sitting blood pressure (systolic, diastolic, and avarage blood pressure) -Proportion of patients achieving 24 hr and sitting blood pressure control	—

Measure

Time frame

efficacy -Relationship between the change from baseline in morning, evening, and night blood pressure (systolic, diastolic, and avarage blood pressure) and baseline factors. -Relationship between the change from baseline in sitting blood pressure (systolic and diastolic blood pressure) and baseline factors. -Change from baseline in sitting blood pressure (systolic and diastolic blood pressure) and baseline factors. -Time course of 24 hr blood pressure and sitting blood pressure (systolic, diastolic, and avarage blood pressure) -Proportion of patients achieving 24 hr and sitting blood pressure control

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Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026