CMV corneal endotheliitis
Conditions
Sponsors
M's Science Corporation
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients who diagnose as CMV endotheliitis based on the clinical manifestations of (1) or (2). (1) Patients who show coin-shaped lesionsl or inear keratic precipitates (KPs). (2) Patients who show other KPs combined with more than 2 of following signs; anterior uveitis, ocular hypertension and corneal endothelial cell loss. 2) Patients who are CMV DNA positive by examination of qualitative PCR of aqueous humor. 3) Patients who consent for collecting aqueous humor by anterior chamber tap.
Exclusion criteria
Exclusion criteria: 1) Patients who are HSV or VZV positive by examination of qualitative PCR of aqueous humor. 2) Patients who diagnose as CMV endotheliitis with other causes than CMV. 3) Patients who receive anti-CMV drugs such as ganciclovir, valganciclovir or foscarnet within 4 weeks of enrollment. 4) Patients who are allergic to ganciclovir. 5) Patients who diagnose CMV retinopathy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical manifestations, BCVA, IOP, corneal endothelial cell density, central corneal thickness and corneal volume Slit-lamp examination, specular microscope, pentacam or anterior segment OCT | — |
Secondary
| Measure | Time frame |
|---|---|
| CMV DNA copy numbers in aqueous humor Real-time PCR | — |
Outcome results
None listed