Healthy/Mild Cognitive Impairment due to Alzheimer's Disease/Mild-to-moderate Alzheimer's Disease
Conditions
Interventions
investigational material(s)
Generic name etc : LY2599666 (Part A)
INN of investigational material :
Therapeutic category code : 119 Other agents affecting central nervous system
Dosage and Administr
Sponsors
Eli Lilly Japan K.K.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Healthy Participants Part A: -Overtly healthy males or females as determined by medical history and physical examination -Have a body mass index (BMI) between 18.0 and 32.0 kilograms per meter squared (kg/m2), inclusive Participants With Mild Cognitive Impairment or Alzheimer's Disease (AD) [Part B and C]: -Participants are at least 50 years old at screening -Present with Mild Cognitive Impairment (MCI) due to Alzheimer's Disease (AD) or mild-to-moderate AD -Have a caregiver/study informant who provides a separate written informed consent to participate -Have adequate vision and hearing for neuropsychological testing in the opinion of the investigator -Positive florbetapir scan
Exclusion criteria
Exclusion criteria: All Participants -Are currently enrolled in a clinical trial involving an investigational product or off-label use of a drug or device or are concurrently enrolled in any other type of medical research judged not to be scientifically or medically compatible with this study -Have known allergies to LY2599666, solanezumab, or any related compounds or components of the formulations, or have a history of significant atopy -Have an abnormality in the 12-lead electrocardiogram (ECG) that, in the opinion of the investigator, increases the risks associated with participating in the study -Have an abnormal blood pressure as determined by the investigator -Have significant allergies to humanized monoclonal antibodies, diphenhydramine, epinephrine, or methylprednisone -Require treatment with other monoclonal antibodies Participants With Mild Cognitive Impairment or Alzheimer's Disease (AD) [Part B and C] -Have medical or surgical conditions in which lumbar puncture and or/catheter insertion is contraindicated -Have any contraindication for magnetic resonance imaging (MRI) studies, including claustrophobia, the presence of metal (ferromagnetic) implants, or a cardiac pacemaker that is not compatible with MRI Participants With Mild Cognitive Impairment or Alzheimer's Disease (AD) [Part C] -Have had lymphoma, leukemia, or any malignancy within the past 5 years except for basal cell or squamous epithelial carcinomas of the skin that have been resected with no evidence of metastatic disease for 3 years, cervical carcinoma in situ, or in situ prostate cancer with a normal prostate-specific antigen post treatment
Outcome results
None listed