Nosocomial Pneumonia (NP), Ventilator-associated Pneumonia (VAP)
Conditions
Interventions
investigational material(s)
Generic name etc : ceftazidime-avibactam
INN of investigational material :
Therapeutic category code : 619 Other antibiotic preparations (including mixed antibiotic prepar
Sponsors
AstraZeneca
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: -Females can participate if surgically sterile or completed menopause; if able to have children, must have negative serum pregnancy test, agree not to attempt pregnancy and use acceptable contraception while receiving study therapy and for 1 week after -Onset of symptoms 48 hours or more after admission or 38 C) or hypothermia (rectal/core temperature 10,000 cells/mm3, or White blood cell count 15% band forms.
Exclusion criteria
Exclusion criteria: -Pulmonary disease that, in the investigator's judgment, would preclude evaluation of therapeutic response (e.g. lung cancer, active tuberculosis, cystic fibrosis, granulomatous disease, fungal pulmonary infection or recent pulmonary embolism).-Patients with lung abscess, pleural empyema or post obstructive pneumonia. -Patients with an estimated creatinine clearance <16ml/min by Cockcroft Gault formula or patients expected to require haemodialysis or other renal support while on study therapy. -Acute hepatitis in the prior 6 months, cirrhosis, acute hepatic failure or acute decompensation of chronic hepatic failure. -Patients receiving hemodialysis or peritoneal dialysis.
Outcome results
None listed