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A Phase 1, Open-Label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumour Activity of Ascending Doses of AZD1208 in Patients With Advanced Solid Malignancies Including Malignant Lymphoma

A Phase 1, Open-Label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumour Activity of Ascending Doses of AZD1208 in Patients With Advanced Solid Malignancies Including Malignant Lymphoma

Status
Unknown
Phases
Phase 1
Study type
Interventional
Source
JPRN
Registry ID
JPRN-jRCT2080221904
Enrollment
Unknown
Registered
2012-09-04
Start date
2012-09-04
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Advanced Solid Malignancies, Malignant Lymphoma

Interventions

investigational material(s) Generic name etc : AZD1208 INN of investigational material : Therapeutic category code : 429 Other antitumor agents Dosage and Administration for Investigational material

Sponsors

AstraZeneca
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: - Patients who have signed this Written Informed Consent Form after a full explanation about the participation in this study - Patients aged 18 years or older Patients diagnosed with a solid malignant tumour or malignant lymphoma that is refractory to standard therapies or for which no standard therapies exist - Patients with good physical conditions (you can walk and can look after yourself) within the last 2 weeks. - Patients who have at least one lesion that can be accurately assessed

Exclusion criteria

Exclusion criteria: - Patients who have recently received or are receiving prohibited medications or treatments - Patients who have any unresolved side effects of previous treatments - Patients who have spinal cord compression or brain metastases - Patients who have severe systemic diseases (e.g., uncontrolled hypertension, hepatitis B, hepatitis C and human immunodeficiency virus [HIV] infection) - Patients with significant abnormal ECG findings

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026