Healthy Volumteer
Conditions
Interventions
investigational material(s)
Generic name etc : LY110140
INN of investigational material :
Therapeutic category code : 117 Psychotropic agents
Dosage and Administration for Investigational material :
Sponsors
Eli Lilly Japan K.K.
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: [Inclusion Criteria] * Overtly healthy Japanese males (as determined by medical history and physical examination) who agree to use a reliable method of birth control during the study and for 3 months following the last dose of the investigational product. * Have a body mass index (BMI) of 18.5 to 29.9kg/m^2, inclusive, at the time of screening. * Have given written informed consent approved by Lilly and the ethical review board (ERB) governing the study site.
Exclusion criteria
Exclusion criteria: [Exclusion Criteria] * Poor metabolizers of enzyme Cytochrome P450 2D6 (CYP2D6) (assessed at screening). * Have an abnormality in the 12-lead Electrocardiogram (ECG) at screening that, in the opinion of the investigator, increases the risks associated with participating in the study such as, a Bazett's corrected QT(QTcB) intercal >450 millisecounds (msec). * Have any lifetime history of a suicide attempt, or have suicidal ideation or, any suicidal behavior within the last month, or who are at significant risk to commit suicide, as judged by the investigator using the Columbia Suicide Severity Rating Scale (C-SSRS). * Are unsuitable (in the opinion of the investigator or sponsor) for inclusion in the study.
Outcome results
None listed