Acute myocardial infarction
Conditions
Sponsors
TOA EIYO LTD.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Admission to hospital within 6 hrs of the onset of symptoms 2) Chest pain lasting for >= 30 min 3) ST-segment elevation of >= 0.2 mV in 2 or more contiguous precordial leads (V1-V4) on standard 12-lead electrocardiogram 4) TIMI flow grade 0/1 in left anterior descending artery (LAD) on diagnostic coronary angiography (CAG) 5) Written informed consent
Exclusion criteria
Exclusion criteria: 1) Prior documented old myocardial infarction (MI) or a clinical history of definite MI 2) Left main trunk (LMT) stenosis >50% 3) Total occlusion of left circumflex artery (LCX) or right coronary artery (RCA) 4) Left bundle-branch block 5) Suspected acute aortic dissection 6) Cardiac arrest or cardiogenic shock 7) Thrombolytic therapy or coronary artery bypass grafting (CABG) 8) Hepatic and/or renal dysfunction 9) History of allergy or drug hypersensitivity 10) Pregnancy or nursing mothers or childbearing women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Myocardial salvage index at 3-5 days after percutaneous coronary intervention (PCI) 2) Incidence of adverse events and side effects for 7 days after PCI | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Events for 3 months after PCI 2) Incidence of adverse events and side effects for 3 months after PCI 3) MI size, left ventricular function and 12-lead electrocardiogram | — |
Outcome results
None listed