Myocardial Infarction, Cardiovascular Death, Atherothrombosis, Stroke
Conditions
Interventions
investigational material(s)
Generic name etc : Ticagrelor
INN of investigational material :
Therapeutic category code : 339 Other agents relating to blood and body fluides
Dosage and Administration
Sponsors
AstraZeneca
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: - Person who had a heart attack within 1 - 3 years ago and at least one additional risk factor: Age 65 years old or more, Diabetes requiring medication, Documented history of 2nd prior MI (>1 year ago). Angiographic evidence of multivessel CAD, and/or Chronic, non-end stage renal dysfunction. - Females of child-bearing potential must have a negative pregnancy test at enrollment - Persons who are currently taking aspirin between 75 and 150 mg once daily
Exclusion criteria
Exclusion criteria: - Persons who are being treated with agents inhibiting blood clotting if the agent cannot be stopped at study start - Persons who have planned coronary, cerebrovascular, or peripheral arterial Revascularization (invasive surgery) at study start - Person with known bleeding disorders - Persons who need chronic oral anticoagulant therapy or chronic low-molecular-weight heparin - Persons with a history of ischemic stroke - Persons with a history of intracranial bleeding at any time, a tumor or blood vessel abnormality in the brain and/or spinal cord at any time, a history of surgery involving the brain or spinal cord within the last 5 years, or a history of bleeding from the gastrointestinal tract (eg, esophagus, stomach, colon, rectum) within the last 6 months or a major surgery within the last 30 days. - Persons considered to be at risk of bradycardic events unless already treated with a permanent pacemaker - Persons who have had open heart surgery within the past 5 years, unless the person had a heart attack after the surgery - Person with known severe liver disease - Persons with kidney failure requiring dialysis - Persons with life expectancy < 1 year
Outcome results
None listed