Advanced solid tumor
Conditions
Sponsors
Takeda Pharmaceutical Company Limited
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Major inclusion criteria include the following: 1)Men or women, 20 to 74 years old 2)Histologically or cytologically documented and definitively diagnosed, advanced solid tumor that is refractory to standard treatment or for which no curative therapy is available 3)Eastern Cooperative Oncology Group (ECOG) of 0 or 1
Exclusion criteria
Exclusion criteria: Major exclusion criteria include the following: 1)Primary central nervous system (CNS) tumors, including any CNS lymphoma 2)History of CNS metastases 3)Hematological malignancies 4)Unresolved toxicities from prior anti-cancer therapy, defined as having not resolved to CTCAE grade 0 or 1, or to levels specified in the inclusion/exclusion criteria with the exception of alopecia 5)Clinically significant cardiovascular disease within 1 year prior to enrollment, including myocardial infarction, unstable angina, New York Heart Association class 2 or greater heart failure, peripheral vascular disease, cerebrovascular accident, transient ischemic attack, or arrhythmias not controlled by outpatient medication 6)Uncontrolled hypertension [diastolic > 90 mmHg; systolic >150 mmHg]. 7)History of arterial or venous (deep vein) thrombosis within 1 year before enrollment
Outcome results
None listed