DU-176b Phase 3 Clinical Study (Venous Thromboembolism) -Randomized Double-Blind Study of DU-176b in Patients Undergoing Total Knee Arthroplasty with Enoxaparin as an Active Control -

DU-176b Phase 3 Clinical Study (Venous Thromboembolism) - Japan-Taiwan Multicenter Randomized Double-Blind Study of DU-176b in Patients Undergoing Total Knee Arthroplasty with Enoxaparin as an Active Control -

Status

Unknown

Phases

Phase 3

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT2080220701

Enrollment

520

Registered

2009-03-23

Start date

2009-03-23

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing total knee arthroplasty

Interventions

investigational material(s) Generic name etc : DU-176b INN of investigational material : edoxaban Therapeutic category code : 333 Anticoagulants Dosage and Administration for Investigational material

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients undergoing unilateral total knee arthroplasty Patients who are 20-84 years olds

Exclusion criteria

Exclusion criteria: Subjects with risks of hemorrhage Subjects with thromboembolic risks Subjects who weigh less than 40 kg Subjects who are pregnant or suspect pregnancy, or subjects who want to become pregnant

Design outcomes

Primary

Measure	Time frame
Proportion of subjects with venous thromboembolism events	—

Secondary

Measure	Time frame
Proportion of subjects with bleeding events	—

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026