Double-blind study of VAA489 in patients with essential hypertension (factorial study)

Status

Unknown

Phases

Phase 3

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT2080220350

Enrollment

1404

Registered

2007-02-13

Start date

2007-02-13

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension

Interventions

investigational material(s) Generic name etc : VAA489 INN of investigational material : Therapeutic category code : 214 Antihypertensives Dosage and Administration for Investigational material : Oral

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria - Essential hypertension - Outpatients - Male or female aged 20 to 80 years old Exclusion criteria - Secondary hypertension or suspected of having secondary hypertension - A history of malignant hypertension - Severe hypertension - Significant heart, renal, hepatic diseases or significant cerebrovascular disorder Other protocol-defined inclusion/exclusion criteria may apply

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Primary Outcomes: Change from baseline in mean sitting diastolic blood pressure at 8 weeks. Secondary Outcomes: Change from baseline in mean sitting systolic blood pressure (MSSBP) at trough at 8 weeks.; Responder rate for achieving MSDBP < 90 mmHg or a = 10 mmHg decrease compared to baseline.; Diastolic control rate for achieving MSDBP < 90mmHg.; Blood pressure control rate for achieving MSDBP <90 mmHg and MSSBP <140 mmHg.	—

Measure

Time frame

Primary Outcomes: Change from baseline in mean sitting diastolic blood pressure at 8 weeks. Secondary Outcomes: Change from baseline in mean sitting systolic blood pressure (MSSBP) at trough at 8 weeks.; Responder rate for achieving MSDBP < 90 mmHg or a = 10 mmHg decrease compared to baseline.; Diastolic control rate for achieving MSDBP < 90mmHg.; Blood pressure control rate for achieving MSDBP <90 mmHg and MSSBP <140 mmHg.

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Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026